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KMID : 0366119730010020075
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Korean Journal of Applied Microbiology & Bioengineering
1973 Volume.1 No. 2 p.75 ~ p.78
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Studies on Production of Nucleic acid Derivatives by Microoganisms(Ⅳ)
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Abstract
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Effects of nitrogen sources, supplement of vitamins and minerals on the accumulation of 5´-inosinic acid by an adenineless mutant of Brevibacterium ammoniagenes were examined.
Maximal yield of 5´-inosinic acid was attained by the use of yeast extract. as organic nitrogen source Casamino acid supplemented with Mn^(++), Zn^(++) Ca-D-pantothenate and thiamineHCl could be subsitute for it.
Subsequent experiment using the defined medium showed that the concentration of these trace element in the medium affected inosinic acid accumulation markedly. And it was found that the simulataneous addition of Mn^(++) (20㎍/1). Zn^(++)(10㎍/1). thiamine Hcl(10mg/l) and Ca-D-pantothenate(5mg/l) to the defined medium stimulated inosinic acid accumulation, from which 7mg/ml of inosinic acid was obtained.
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